I. Ben Sahra: search on Z-Library

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1

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

Ben Sahra, I., Laurent, K., Giuliano, S., Larbret, F., Ponzio, G., Gounon, P., Le Marchand-Brustel, Y., Giorgetti-Peraldi, S., Cormont, M., Bertolotto, C., Deckert, M., Auberger, P., Tanti, J.-F., Bos

Journal:

Cancer Research

Year:

2010

Language:

english

File:

PDF, 617 KB

english, 2010

2

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

Ben Sahra, I., Le Marchand-Brustel, Y., Tanti, J.-F., Bost, F.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 303 KB

english, 2010

3

A growing role for mTOR in promoting anabolic metabolism

Howell, Jessica J., Ricoult, Stéphane J.H., Ben-Sahra, Issam, Manning, Brendan D.

Journal:

Biochemical Society Transactions

Year:

2013

Language:

english

File:

PDF, 365 KB

english, 2013

4

mTORC1 signaling and the metabolic control of cell growth

Ben-Sahra, Issam, Manning, Brendan D

Journal:

Current Opinion in Cell Biology

Year:

2017

Language:

english

File:

PDF, 962 KB

english, 2017

5

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H 2 S Production

Longchamp, Alban, Mirabella, Teodelinda, Arduini, Alessandro, MacArthur, Michael R., Das, Abhirup, Treviño-Villarreal, J. Humberto, Hine, Christopher, Ben-Sahra, Issam, Knudsen, Nelson H., Brace, Lear

Journal:

Year:

2018

Language:

english

File:

PDF, 5.57 MB

english, 2018

6

Direct stimulation of NADP + synthesis through Akt-mediated phosphorylation of NAD kinase

Hoxhaj, Gerta, Ben-Sahra, Issam, Lockwood, Sophie E., Timson, Rebecca C., Byles, Vanessa, Henning, Graham T., Gao, Peng, Selfors, Laura M., Asara, John M., Manning, Brendan D.

Journal:

Year:

2019

Language:

english

File:

PDF, 966 KB

english, 2019

7

Obésité et cancers du côlon et de la prostate: implication des adipokines

I. Ben Sahra, Y. Le Marchand Brustel, J. -F. Tanti, F. Bost

Journal:

Year:

2008

File:

PDF, 225 KB

2008

8

Un nouveau mécanisme de régulation de PTEN par la PI3-kinase

Journal:

Year:

2011

Language:

french

File:

PDF, 597 KB

french, 2011

9

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

Sahra, I Ben, Laurent, K, Loubat, A, Giorgetti-Peraldi, S, Colosetti, P, Auberger, P, Tanti, J F, Le Marchand-Brustel, Y, Bost, F

Journal:

Year:

2008

Language:

english

File:

PDF, 320 KB

english, 2008

10

O45 La metformine exerce un effet anti-tumoral et entraîne un arrêt du cycle cellulaire

I. Ben Sahra, K. Laurent, A. Loubat, S.G. Peraldi, P. Colosetti, P. Auberger, J.F. Tanti, Y. Le Marchand-Brustel, F. Bost

Journal:

Diabetes & Metabolism

Year:

2008

Language:

french

File:

PDF, 113 KB

french, 2008

11

O49 L’hypoxie inhibe la voie de signalisation de l’insuline dans les adipocytes

C. Regazzetti, P. Peraldi, I. Ben-Sahra, M. Cormont, F. Bost, Y. Le Marchand-Brustel, J.F. Tanti, S. Giorgetti-Peraldi

Journal:

Diabetes & Metabolism

Year:

2009

Language:

french

File:

PDF, 76 KB

french, 2009

12

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

Ben-Sahra, I., Howell, J. J., Asara, J. M., Manning, B. D.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.30 MB

english, 2013

13

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

Ben-Sahra, I, Dirat, B, Laurent, K, Puissant, A, Auberger, P, Budanov, A, Tanti, J-F, Bost, F

Journal:

Cell Death & Differentiation

Year:

2013

Language:

english

File:

PDF, 1.47 MB

english, 2013

14

The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells

Rosilio, Célia, Lounnas, Nadia, Nebout, Marielle, Imbert, Véronique, Hagenbeek, Thijs, Spits, Hergen, Asnafi, Vahid, Pontier-Bres, Rodolphe, Reverso, Julie, Michiels, Jean-François, Ben Sahra, Issam,

Journal:

Year:

2013

Language:

english

File:

PDF, 1.20 MB

english, 2013

15

Metformin: A metabolic disruptor and anti-diabetic drug to target human leukemia

Rosilio, Célia, Ben-Sahra, Issam, Bost, Frédéric, Peyron, Jean-François

Journal:

Year:

2014

Language:

english

File:

PDF, 1.06 MB

english, 2014

16

mTORC1 stimulates nucleotide synthesis through both transcriptional and post-translational mechanisms

Ben-Sahra, Issam, Ricoult, Stephane, Howell, Jessica, Asara, John, Manning, Brendan

Journal:

Cancer & Metabolism

Year:

2014

Language:

english

File:

PDF, 82 KB

english, 2014

17

Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response

Lall, R, Ganapathy, S, Yang, M, Xiao, S, Xu, T, Su, H, Shadfan, M, Asara, J M, Ha, C S, Ben-Sahra, I, Manning, B D, Little, J B, Yuan, Z-M

Journal:

Cell Death & Differentiation

Year:

2014

Language:

english

File:

PDF, 1.93 MB

english, 2014

18

Hypoxia Decreases Insulin Signaling Pathways in Adipocytes

Regazzetti, C., Peraldi, P., Gremeaux, T., Najem-Lendom, R., Ben-Sahra, I., Cormont, M., Bost, F., Le Marchand-Brustel, Y., Tanti, J.-F., Giorgetti-Peraldi, S.

Journal:

Year:

2009

Language:

english

File:

PDF, 1.15 MB

english, 2009

19

The TSC-mTOR pathway regulates macrophage polarization

Byles, Vanessa, Covarrubias, Anthony J., Ben-Sahra, Issam, Lamming, Dudley W., Sabatini, David M., Manning, Brendan D., Horng, Tiffany

Journal:

Nature Communications

Year:

2013

Language:

english

File:

PDF, 790 KB

english, 2013

20

ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis

Liu, Xue-Song, Haines, Jenna E., Mehanna, Elie K., Genet, Matthew D., Ben-Sahra, Issam, Asara, John M., Manning, Brendan D., Yuan, Zhi-Min

Journal:

Genes & Development

Year:

2014

Language:

english

File:

PDF, 2.12 MB

english, 2014

21

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

Ben Sahra, I., Regazzetti, C., Robert, G., Laurent, K., Le Marchand-Brustel, Y., Auberger, P., Tanti, J.-F., Giorgetti-Peraldi, S., Bost, F.

Journal:

Cancer Research

Year:

2011

Language:

english

File:

PDF, 847 KB

english, 2011

22

The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

Ben Sahra, Issam, Tanti, Jean-François, Bost, Frédéric

Journal:

Year:

2010

Language:

english

File:

PDF, 364 KB

english, 2010

23

Imatinib triggers mesenchymal-like conversion of CML cells associated with increased aggressiveness

Puissant, A., Dufies, M., Fenouille, N., Ben Sahra, I., Jacquel, A., Robert, G., Cluzeau, T., Deckert, M., Tichet, M., Cheli, Y., Cassuto, J.-P., Raynaud, S., Legros, L., Pasquet, J.-M., Mahon, F.-X.,

Journal:

Journal of Molecular Cell Biology

Year:

2012

Language:

english

File:

PDF, 857 KB

english, 2012

24

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP

Ricoult, S J H, Yecies, J L, Ben-Sahra, I, Manning, B D

Journal:

Year:

2015

Language:

english

File:

PDF, 2.85 MB

english, 2015

25

Prevention of Mutagenesis: New Potential Mechanisms of Metformin Action in Neoplastic Cells

Bost, F., Ben-Sahra, I., Tanti, J.-F.

Journal:

Cancer Prevention Research

Year:

2012

Language:

english

File:

PDF, 391 KB

english, 2012

26

Metformin and cancer therapy

Bost, Frédéric, Sahra, Issam Ben, Le Marchand-Brustel, Yannick, Tanti, Jean-François

Journal:

Current Opinion in Oncology

Year:

2012

Language:

english

File:

PDF, 268 KB

english, 2012

27

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

Fenouille, Nina, Bassil, Christopher F, Ben-Sahra, Issam, Benajiba, Lina, Alexe, Gabriela, Ramos, Azucena, Pikman, Yana, Conway, Amy S, Burgess, Michael R, Li, Qing, Luciano, Frédéric, Auberger, Patri

Journal:

Nature Medicine

Year:

2017

Language:

english

File:

PDF, 2.53 MB

english, 2017

28

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells

Loubiere, Camille, Clavel, Stephan, Gilleron, Jerome, Harisseh, Rania, Fauconnier, Jeremy, Ben-Sahra, Issam, Kaminski, Lisa, Laurent, Kathiane, Herkenne, Stephanie, Lacas-Gervais, Sandra, Ambrosetti,

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.04 MB

english, 2017

29

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels

Hoxhaj, Gerta, Hughes-Hallett, James, Timson, Rebecca C., Ilagan, Erika, Yuan, Min, Asara, John M., Ben-Sahra, Issam, Manning, Brendan D.

Journal:

Year:

2017

Language:

english

File:

PDF, 5.44 MB

english, 2017

30

Recovery from N Deprivation Is a Transcriptionally and Functionally Distinct State in Chlamydomonas

Tsai, Chia-Hong, Uygun, Sahra, Roston, Rebecca, Shiu, Shin-Han, Benning, Christoph

Journal:

PLANT PHYSIOLOGY

Year:

2017

Language:

english

File:

PDF, 2.06 MB

english, 2017

31

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

Covarrubias, Anthony J, Aksoylar, Halil Ibrahim, Yu, Jiujiu, Snyder, Nathaniel W, Worth, Andrew J, Iyer, Shankar S, Wang, Jiawei, Ben-Sahra, Issam, Byles, Vanessa, Polynne-Stapornkul, Tiffany, Espinos

Journal:

Year:

2016

Language:

english

File:

PDF, 2.43 MB

english, 2016

32

HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth

Ben-Sahra, Issam, Puissant, Alexandre

Journal:

Cell Metabolism

Year:

2018

Language:

english

File:

PDF, 536 KB

english, 2018

33

Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS

Yuan, Min, Kremer, Daniel M., Huang, He, Breitkopf, Susanne B., Ben-Sahra, Issam, Manning, Brendan D., Lyssiotis, Costas A., Asara, John M.

Journal:

Nature Protocols

Year:

2019

File:

PDF, 2.14 MB

2019

34

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Zhang, Shuang, Weinberg, Samuel, DeBerge, Matthew, Gainullina, Anastasiia, Schipma, Matthew, Kinchen, Jason M., Ben-Sahra, Issam, Gius, David R., Charvet, Laurent Yvan-, Chandel, Navdeep S., Schumacke

Journal:

Cell Metabolism

Year:

2018

Language:

english

File:

PDF, 4.33 MB

english, 2018

35

Radiocarbon dating and isotope analysis on the purported Aurignacian skeletal remains from Fontana Nuova (Ragusa, Italy)

Di Maida, Gianpiero, Mannino, Marcello A., Krause-Kyora, Ben, Jensen, Theis Zetner Trolle, Talamo, Sahra, Peresani, Marco

Journal:

Year:

2019

Language:

english

File:

PDF, 1.67 MB

english, 2019

36

Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides

Villa, Elodie, Ali, Eunus, Sahu, Umakant, Ben-Sahra, Issam

Journal:

Year:

2019

Language:

english

File:

PDF, 1.49 MB

english, 2019

37

ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis

Ali, Eunus S., Sahu, Umakant, Villa, Elodie, OâHara, Brendan P., Gao, Peng, Beaudet, Cynthia, Wood, Antony W., Asara, John M., Ben-Sahra, Issam

Journal:

Year:

2020

File:

PDF, 4.53 MB

2020

38

A spoonful of DHAP keeps mTORC1 running on sugars

Hoxhaj, Gerta, Locasale, Jason W., Ben-Sahra, Issam

Journal:

Nature Metabolism

Year:

2020

File:

PDF, 887 KB

2020

39

ASS1igning purine dependency to cancer

Villa, Elodie, Ben-Sahra, Issam

Journal:

Year:

2020

File:

PDF, 810 KB

2020

40

DRES-09. REGULATORY EFFECTS OF THE CILIARY GTPASE ARL13B ON PURINE METABOLISM IN GBM

Saathoff, Miranda, Shireman, Jack, Ali, Eunus, Park, Cheol, Ben-Sahra, Issam, Ahmed, Atique

Journal:

Year:

2019

File:

PDF, 96 KB

2019